By Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)
The present explosion of latest parts of controversy within the remedy of acute lymphocytic leukemia in adults and teens makes this complete ebook a far wanted reference for hematologists and oncologists. This publication assembles top experts from world wide to hide the complete spectrum of ALL subtypes and their remedies. particular issues of dialogue comprise symptoms for allogeneic bone marrow transplant in first entire remission, the position of minimum residual affliction in making therapy judgements, the remedy of teenagers, and the therapy of Philadelphia chromosome confident ALL with the arrival of the tyrosine kinase inhibitors. this is often the 1st e-book to concentration completely at the grownup ALL sufferer. It offers an entire assessment of prognosis, molecular pathogenesis, overview, and therapy for this crucial sufferer population.
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Additional resources for Adult Acute Lymphocytic Leukemia: Biology and Treatment
Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia. Blood, 107(3), 1116–1123. 84. , et al. (2007). Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: Data from the GMALL 06/99 and 07/03 trials. Blood, 109(3), 910–915. 85. , et al. (2002). Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia.
Genetic characterization of this group revealed deletions in genes involved in B-cell development in about 80% of cases, similar to that seen in Ph+ ALL . The transcription profile of this poor prognosis group was also similar to that seen in Ph+ ALL . Conversely, GEP studies have yielded somewhat limited results in predicting outcome in other groups of ALL patients. Transcription profiles associated with outcome have not succeeded in adding additional predictive information to clinical and genetic factors already used in risk assessment in pediatric patients , or have failed inter-study validation [95–97].
2008). Musculoskeletal manifestations in pediatric acute leukemia. Journal of Pediatric Orthopedics, 28(1), 20–28. 19. , et al. (2006). Leukaemia cutis in T-cell acute lymphoblastic leukaemia. Cytopathology, 17(3), 158–161. 20. , et al. (2000). Hyperleukocytic leukemias and leukostasis: A review of pathophysiology, clinical presentation and management. Leukaemia & Lymphoma, 39(1–2), 1–18. 21. Maurer, H. , et al. (1988). The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia.