By Jay D. Humphrey, Sherry L. O'Rourke
Designed to fulfill the wishes of undergraduate scholars, Introduction to Biomechanics takes the clean procedure of mixing the viewpoints of either a well-respected instructor and a winning pupil. With an eye fixed towards practicality with out lack of intensity of guideline, this ebook seeks to give an explanation for the elemental ideas of biomechanics. With the accompanying site delivering types, pattern difficulties, overview questions and extra, Introduction to Biomechanics offers scholars with the complete diversity of educational fabric for this complicated and dynamic box.
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Additional resources for An Introduction to Biomechanics: Solids and Fluids, Analysis and Design
2002). The GAGs are often bound covalently to protein cores, thus forming proteoglycans. Although collagen was long regarded to be a single protein, more than 16 distinct forms have been identified. Collectively, the collagens are the most abundant protein in the body (-25-30% of all protein), common forms being types I, II, III, and IV, as well as types V, VI, and VIII. Types I and III form fibers and provide structural support in tension; they are found in tendons, skin, bone, the heart, arteries, and cornea.
1989)]. , in tendons, the collagen tends to be oriented uniaxially, whereas in skin, it is distributed primarily in a two-dimensional (2-D) fashion]. um in diameter), the specific diameter of which is also thought to be dictated largely by the mechanical force field in the ECM. The extracellularly organized fibrils and fibers are stabilized by interchain cross-links that occur primarily through the conversion of lysine and hydroxylysine (in the nonhelical portion of the molecule), via the enzyme lysyl oxidase, into peptide-bound aldehydes.
The student is encouraged to read, for example, the provocative paper by Ingber et al. (2000), which contrasts two ideas on how the intracellular forces balance the externally applied loads. One idea is based on tensegrity (tensional integrity), an architectural concept advanced by Buckminster Fuller wherein a stable structure is con- 24 1. Introduction structed from self-equilibrating tensional and compressive elements; the other idea focuses on the combined fluidlike and solidlike behaviors exhibited by cells under different conditions.