Bioactive Proteins and Peptides as Functional Foods and by Yoshinori Mine Ph.D, Eunice Li-Chan, Bo Jiang

By Yoshinori Mine Ph.D, Eunice Li-Chan, Bo Jiang

Bioactive Proteins and Peptides as practical meals and Nutraceuticals highlights fresh advancements of nutraceutical proteins and peptides for the merchandising of human overall healthiness. The publication considers basic suggestions and structure-activity relatives for the foremost sessions of nutraceutical proteins and peptides. insurance comprises useful proteins and peptides from various assets together with: soy, Pacific hake, bovine muscle, peas, wheat, fermented milk, eggs, casein, fish collagen, bovine lactoferrin, and rice. The foreign panel of specialists from and academia additionally stories present purposes and destiny possibilities in the nutraceutical proteins and peptides zone.

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2001 ↓ TNF-α, ↓ IL-10, ↓ IL-12, ↓ IL-6, ↓ IL-1β Inhibits lymphocyte proliferation Secretion of IL-1ra Mikkelsen et al. 2005 ↓ IL-1β ↓ IL-2 receptor expression ↓ IL-1, ↓ iNOS mRNA, ↓ IL-17 ↓ TNF-α, ↓ IL-6 ↓ TNF-α, ↓ IL-1β, ↓ IL-6, ↑ IL-4, ↑ IL-10 ↓ infiltrating leukocytes ↓ TNF-α-producing spleen cells ↓ TNF-α, ↑ IL-10 ↓ TNF-α, ↓ IL-1β, ↓ IL-6, ↓ IL-8 protein and mRNA, ↓ NF-κB ↓ TNF-α Inhibits proliferation Inhibits hemolytic activity of serum complement ↓ TNF-α, ↓ IL-6, ↓ IL-1β, ↓ ERK1/2, JNK and p38 MAPK, ↓ NF-κB ↓ NO, ↓ prostaglandin E2 ↓ in histopathological inflammation ↓ disease activity index ↓ NF-κB and AP-1, ↓ activities of iNOS, COX-2, MMP-9, ↓ TNF-α, ↓ IL-6 ↓ PKC, ↓ NF-κB, ↓ AP-1, ↓ iNOS, ↓ COX-2 Otani and Odashima 1987 Otani et al.

2006). Melatonin is generally more effective than vitamin E and glutathione in neutralizing •OH, • OOR, O2−i, NO, singlet oxygen, and hydrogen peroxide. Furthermore, melatonin, along with epithalamin and epitalon from the pineal gland, possesses strong ROS-scavenging activity. Epithalamin from bovine brain and its active fragment epitalon (Ala-Glu-Asp-Gly) are able to stimulate melatonin production as well as the expression of antioxidant enzymes superoxide dismutase and ceruloplasmin (Kozina et al.

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