Biochemical Engineering and Biotechnology by Ghasem Najafpour

By Ghasem Najafpour

Wide program of bioprocesses has generated a diffusion in biotechnological wisdom, generated by means of the appliance of biochemical engineering to biotechnology. Microorganisms produce alcohols and acetone which are utilized in commercial methods. the data concerning commercial microbiology has been revolutionized by means of the facility of genetically engineered cells to make many new items. Genetic engineering and gene mounting has been built to reinforce commercial fermentation. eventually, those bioprocesses became a brand new approach of constructing advertisement items. Biochemical Engineering and Biotechnology demonstrates the appliance of organic sciences in engineering with theoretical and functional features to reinforce knowing of data during this box. The ebook adopts a realistic process, displaying similar case experiences with unique learn information. it really is an incredible textual content booklet for faculty and collage classes, which courses scholars in the course of the lectures in a transparent and well-illustrated demeanour. · Demonstrates the applying of organic sciences in engineering with theoretical and useful points. · special useful procedure, utilizing case experiences, unique experiments, unique study info and difficulties and attainable options. · supplies specified experiments with easy layout equations and the mandatory calculations.

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If copper sulphate is accidentally added to the fermentation broth, which may reduce the oxygen uptake rate to 3 mmol gϪ1 hϪ1 and inhibit the microbial cell growth, what would be the maximum cell density in this condition? 1) Solution We make an assumption based on the fact that all of the dissolved oxygen in the fermentation broth is used or taken by microorganisms. In this case the DO goes to zero. The value for CAL can be zero since it is not given in the problem statement. Also the cell density has to be maximised.

Comparing a disk turbine agitator with an intermig agitator, this type results in a more uniform energy transfer to the fluid in the vessel. Therefore this type of agitator requires less power and less air input to obtain the same degree of mixing and the same mass transfer coefficient. 11 GAS–LIQUID PHASE MASS TRANSFER There is always a limit to the liquid phase oxygen transfer for high cell density because mass transfer is limited. Actual cases are: • In a large-scale fermenter for penicillin production; or • In extracellular biopolymers such as xantham gum; • In wastewater treatment with an activated sludge system Gas and liquid systems are explained by solubility.

Am. 245, 77 (1981). 1 INTRODUCTION In biochemical engineering processes, measurement of dissolved oxygen (DO) is essential. The production of SCP may reach a steady-state condition by keeping the DO level constant, while the viable protein is continuously harvested. The concentration of protein is proportional to oxygen uptake rate. Control of DO would lead us to achieve steady SCP production. Variation of DO may affect retention time and other process variables such as substrate and product concentrations, retention time, dilution rate and aeration rate.

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